Three genera of free-living amebas, Naegleria, Acanthamoeba, and B mandrillaris are known to infect humans. Naegleria fowleri causes an acute and almost invariably fatal encephalitis, which, fortunately, is rare. Several species of Acanthamoeba and B mandrillaris can cause lung and skin infections, as well as an insidious encephalitis, in immunocompromised patients.In addition, Acanthamoeba may cause an ulcerative keratitis, which is usually associated with improper sterilization of soft contact lenses. These amebas live freely in soil and in fresh and coastal waters. The resistant cysts can be transported in dust.